Homeodomain-interacting protein kinase 2 and tumor signal transduction
10.3760/cma.j.issn.1673-422X.2011.06.001
- VernacularTitle:同源结构域相互作用蛋白激酶2与肿瘤信号传导
- Author:
Lihong ZHOU
;
Shujun CI
;
Qi LI
- Publication Type:Journal Article
- Keywords:
Neoplasms;
Homeodomain proteins;
Signal transduction
- From:
Journal of International Oncology
2011;38(6):403-406
- CountryChina
- Language:Chinese
-
Abstract:
Homeodomain-interacting protein kinase 2(HIPK2)is a member of a member of the serine/threonine protein kinase family which localized in the mucleus.It is not only involved in advanced stage embryogenesis,development of nerve tissue,retina and muscular tissue,but also takes part in regulation of tumor signaling transduction,down-modulated expression of oncogene,induced apoptosis of tumor cells,and inhibited angiogeuesis of tumor.The regulation of HIPK2 in tumor signaling transduction pathway is associated with P53 signaling,Wnt/β-catenin pathway and hypoxia.
