Effects of chitosan/modified chitosan DNA nanoparticles on the differentiation of human naive CD4+ T cells
10.3760/cma.j.issn.1673-4181.2011.02.007
- VernacularTitle:壳聚糖及其修饰物载基因纳米粒子对人初始CD4+T细胞分化的影响
- Author:
Lanxia LIU
;
Dunwan ZHU
;
Xia DONG
;
Liping SONG
;
Hailing ZHANG
;
Xigang LENG
- Publication Type:Journal Article
- Keywords:
Chitosan;
Nanoparticle;
Naive CD4+ T cell;
Gene vector;
Immuntoxicity
- From:
International Journal of Biomedical Engineering
2011;34(2):91-93
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the impact of chitosan and alkylated chitosan DNA nanoparticles on the function of human naive CD4+T cells.Methods The secretion of cytokines (IL-4 and TNF-γ) was observed after the co-incubation of human naive CD4+T cells with nanoparticles 12 h,24 h and 48 h,respectively.ResultsNone of the nanoparticles induced the production of cytokines ( IL-4 and TNF-γ ).Conclusion Chitosan and alkylated chitosan DNA nanoparticles will not induce the differentiation of human naive CD4+ T cells into T1 or T2 and may be considered as a safe gene carrier.
