Uncoupling protein 4 and its roles in the central nervous system diseases
10.3760/cma.j.issn.1673-4165.2011.06.014
- VernacularTitle:解耦联蛋白4及其在中枢神经系统疾病中的作用
- Author:
Haichao LIU
;
Ruichun LIU
;
Yuanyuan DU
;
Hui JI
;
Xiangjian ZHANG
- Publication Type:Journal Article
- Keywords:
Carrier proteins;
Mitochondrial uncoupling protein;
Oxidative stress;
Central nervous system diseases;
Brain ischemia
- From:
International Journal of Cerebrovascular Diseases
2011;19(6):471-475
- CountryChina
- Language:Chinese
-
Abstract:
Uncoupling protein 4 (UCP4) is a member of the multigenic uncoupling proteins (UCPs), specific expressing in the cerebral cortex and hippocampus. UCP4 plays an important role in Parkinson's disease, multiple sclerosis, epilepsy, stroke, brain trauma and other central nervous system diseases by uncoupling, decreasing mitochondrial membrane potential,regulating Ca2+ homeostasis and oxidative stress. This article reviews UCP4 and its roles in the central nervous system diseases in order to provide certain basis for the development of UCP4targeted medication.
