Notch3 signaling pathway and cerebrovascular diseases
10.3760/cma.j.issn.1673-4165.2011.06.012
- VernacularTitle:Notch3信号通路与脑血管病
- Author:
Ying LI
;
Weiwei ZHANG
;
Jing LI
- Publication Type:Journal Article
- Keywords:
NOTCH3 protein,human;
Receptors,Notch;
Signal transduction;
Brain ischemia;
Cerebrovascular disorders;
CADASIL
- From:
International Journal of Cerebrovascular Diseases
2011;19(6):461-465
- CountryChina
- Language:Chinese
-
Abstract:
The Notch pathway is an evolutionarily conserved signal transduction pathway. It consists of a complex system of interaction. Its function is associated with the embryonic development and cell differentiation regulation. Studies in recent years have demonstrated that Notch pathway is associated with specific human diseases, in which Notch3 signaling pathway is closely associated with the nervous system development and the structural integrity of blood vessels. Notch3 mutation may cause cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy.
