Pathophysiologic mechanisms in cerebral amyloid angiopathy
10.3760/cma.j.issn.1673-4165.2011.06.011
- VernacularTitle:脑淀粉样血管病的病理生理学机制
- Author:
Huanchang SHI
- Publication Type:Journal Article
- Keywords:
Cerebral amyloid angiopathy;
Amyloid β-peptides;
Apolipoproteins E
- From:
International Journal of Cerebrovascular Diseases
2011;19(6):457-460
- CountryChina
- Language:Chinese
-
Abstract:
Cerebral amyloid angiopathy (CAA) is characterized by leptomeningeal and β-amyloid deposition in arteriole wall in cortex, and it is one of the common cerebral vascular diseases in the elderly. It is correlated with Alzheimer's disease, intracerebral hemorrhage, cerebral infarction and leukoencephalopathy. CAA is divided into hereditary and sporadic types, and the latter is most common. This article reviews the advances in research on the pathophysiological mechanisms of sporadic CAA, particularly the production of β-amyloid protein and clearance mechanism in brain tissue.
