Correlation between Val279Phe, Ile198Thr mutation in lipoprotein-associated phospholipase A2 gene and cerebral infarction
10.3760/cma.j.issn.1673-4165.2011.06.007
- VernacularTitle:脂蛋白相关磷脂酶A2基因Val279Phe和Ile198Thr突变与脑梗死的相关性
- Author:
Jian WU
;
Xiong ZHANG
;
Chenglin YUAN
;
Hengzhong ZHANG
;
Long YU
- Publication Type:Journal Article
- Keywords:
1-Alky1-2-acetylglycerophosphocholine esterase;
Phospholipases A2;
Brain infarction;
Polymorphism,genetic;
Biological markers
- From:
International Journal of Cerebrovascular Diseases
2011;19(6):437-441
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between the mutation in serum lipoprotein-associated phospholipase A2(Lp-PLA2) Ile198Thr, Val279Phe and cerebral infarction in Chinese Han population of Jiangsu Province. Methods One hundred fifty patients with cerebral infarction and 100 healthy controls in Chinese Han population of Jiangsu Province were recruited. The correlation between Val279Phe and Ilel98Thr mutation in Lp-PLA2 gene and cerebral infarction was analyzed using polymerase chain reaction and denaturing high performance liquid chromatography. Results The Val279Phe genotype and the mutant allele frequency in the cerebral infarction group were significantly higher than those in the control group (χ2 were 6. 31and 5. 32, respectively, all P ＜0. 05), and there was no significant difference between the Ile198Thr genotype and the mutant allele frequency in the control group (χ2 were 0. 039 and 0. 037, respectively, all P ＞0. 05). Conclusions The Val279Phe mutation in Lp-PLA2 gene may be a genetic risk factor for cerebral infarction in Chinese Han population of Jiangsu Province.
