Identification role of plasma high sensitive C-reactive protein and lipoprotein (a) levels in the diagnosis of ischemic stroke according to the TOAST classification
10.3760/cma.j.issn.1673-4165.2011.06.005
- VernacularTitle:血浆超敏C反应蛋白和脂蛋白(a)水平在缺血性卒中新TOAST分型诊断中的鉴别作用
- Author:
Mingshan REN
;
Yi YANG
- Publication Type:Journal Article
- Keywords:
Stroke;
Brain schema;
C-Reactive protein;
Lipoprotein(a);
Risk factors
- From:
International Journal of Cerebrovascular Diseases
2011;19(6):427-431
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the identification role of plasma high sensitive Creactive protein (hs-CRP) and lipoprotein (a) (Lp [a]) levels in the diagnosis of patients with acute ischemic stroke according to the TOAST classification. Methods The levels of plasma hsCRP and Lp (a) in 82 acute stroke patients ( ＜24 hours) and 60 healthy controls were detected using immune scatter turbidimetry and immune transmission turbidity, and try to make use of Holter, ultrasonography, magnetic resonance imaging, magnetic resonance angiography/CT angiography/dagital subtraction angiography and other tests. Finally, they were classified according to the diagnostic criteria of the TOAST classification of ischemic stroke. Results There were significant differences in plasma hs-CRP and Lp (a) levels between all the subtypes of the acute ischemic sroke group and the control group (all P ＜0. 001). The the level of plasma hsCRP in patients with cardioembolism (CE) was highest. Hs-CRP could be used as a biological marker of CE subtype (odds ratio[OR] = 1. 84,95% confidence interval [CI] 1. 18-2. 85, P ＜ 0. 05). When its concentration was ＞ 3. 48 mg/L, the sensitivity and specificity of predicting CE were 89% and 83% respectively. The plasma level of the AT patients was highest, it could be used as a biological marker of AT subtype (OR = 1. 02, 95% CI 1. 01-1. 03, P＜0. 05); when its concentration was ＞ 183. 5 mg/L, the sensitivity and specificity of predicting AT were 87% and 85% respectively. Conclusions The plasma hs-CRP and Lp (a) levels of patients with acute ischemic stroke may provide some help for timely and accurate etiological typing.
