High Dose Involved Field Radiation Therapy as Salvage for Loco-Regional Recurrence of Non-Small Cell Lung Cancer.
10.3349/ymj.2012.53.6.1120
- Author:
Sun Hyun BAE
1
;
Yong Chan AHN
;
Heerim NAM
;
Hee Chul PARK
;
Hong Ryull PYO
;
Young Mog SHIM
;
Jhingook KIM
;
Kwhanmien KIM
;
Jin Seok AHN
;
Myung Ju AHN
;
Keunchil PARK
Author Information
1. Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. ahnyc@skku.edu
- Publication Type:Original Article
- Keywords:
Concurrent chemo-radiation therapy;
locoregional recurrence;
non-small cell lung cancer;
radiation therapy;
salvage treatment
- MeSH:
Aged;
Aged, 80 and over;
Carcinoma, Non-Small-Cell Lung/mortality/*radiotherapy/surgery;
Female;
Humans;
Lung Neoplasms/mortality/*radiotherapy/surgery;
Male;
Middle Aged;
Neoplasm Recurrence, Local/*radiotherapy/surgery;
Survival Rate;
Treatment Outcome
- From:Yonsei Medical Journal
2012;53(6):1120-1127
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: To determine the effectiveness of salvage radiation therapy (RT) in patients with loco-regional recurrences (LRR) following initial complete resection of non-small cell lung cancer (NSCLC) and assess prognostic factors affecting survivals. MATERIALS AND METHODS: Between 1994 and 2007, 64 patients with LRR after surgery of NSCLC were treated with high dose RT alone (78.1%) or concurrent chemo-radiation therapy (CCRT, 21.9%) at Samsung Medical Center. Twenty-nine patients (45.3%) had local recurrence, 26 patients (40.6%) had regional recurrence and 9 patients (14.1%) had recurrence of both components. The median RT dose was 54 Gy (range, 44-66 Gy). The radiation target volume included the recurrent lesions only. RESULTS: The median follow-up time from the start of RT in survivors was 32.0 months. The rates of in-field failure free survival, intra-thoracic failure free survival and extra-thoracic failure free survival at 2 years were 52.3%, 33.9% and 59.4%, respectively. The median survival after RT was 18.5 months, and 2-year overall survival (OS) rate was 47.9%. On both univariate and multivariate analysis, the interval from surgery till recurrence and CCRT were significant prognostic factors for OS. CONCLUSION: The current study demonstrates that involved field salvage RT is effective for LRR of NSCLC following surgery.
