Embryonic stem cells against Lewis non-small cell lung cancer in vivo

VernacularTitle:胚胎干细胞抗Lewis非小细胞肺癌作用的体内研究
Author: Jiajun DU ; Bujian TANG ; Qi LIU
Publication Type:Journal Article
Keywords: Stem cells Carcinoma; non-small-cell lung Antitumor response
From: Chinese Journal of Thoracic and Cardiovascular Surgery 2011;27(5):304-307
CountryChina
Language:Chinese
Abstract: Objective To investigate the function and mechanism of embryonic stem cells against Lewis non-small cell lung cancer in vivo. Methods Based on the mouse Lewis non-small cell lung cancer model, we have tested some tumor growth indexes and investigated the immune response of embryonic stem cells against cancer cells. Results Compared with the mice in control group, mice in experimental group received obvious antitumor immunity, which means more activated lymphocytes and antitumor cytokines, resulted in the effective control and inhibition of tumor development. Conclusion Besides the antitumor effect in vitro, embryonic stem cells can also generates immune response in vivo, which could effectively inhibit and/or delay the development of cancer.