Association of CDKN2B-AS1 rs1333049 with Brain Diseases: A Case-control Study and a Meta-analysis.
- Author:
Jikuang ZHAO
1
;
Xizheng WU
;
Sheng NIE
;
Xiang GAO
;
Jie SUN
;
Keqin LI
;
Tiefeng ZHANG
;
Yi HUANG
Author Information
- Publication Type:Meta-Analysis ; Original Article
- Keywords: Hemorrhagic stroke; Cerebrovascular disease; CDKN2BAS1; rs1333049; Lipid concentration
- MeSH: Asian Continental Ancestry Group; Brain Diseases*; Brain Neoplasms; Brain*; Case-Control Studies*; Cerebrovascular Disorders; Cholesterol; Freezing; Genotype; Humans; Incidence; Lipoproteins; Methods; Stroke
- From:Clinical Psychopharmacology and Neuroscience 2017;15(1):53-58
- CountryRepublic of Korea
- Language:English
- Abstract: OBJECTIVE: CDKN2B-AS1 polymorphisms were shown to associate with the risk of stroke in European. The goal of this study was to evaluate the contribution of CDKN2B-AS1 rs1333049 to the risk of hemorrhagic stroke (HS) and brain tumor (BT) in Han Chinese. METHODS: A total of 142 HSs, 115 BTs, and 494 controls were included in the current association study. The genotyping test was performed using the melting temperature shift method. RESULTS: We failed to validate the association of CDKN2B-AS1 rs1333049 with the risk of brain disease. Significantly higher levels of low-density lipoprotein cholesterol (LDL-C) (p=0.027), high-density lipoprotein cholesterol (HDL-C) (p<0.001) and total cholesterol (TC) (p<0.001) were found in HSs in the genotype GG/GC carriers, but not the genotype CC carriers (p>0.05). The meta-analysis of 10 studies among 133,993 individuals concluded that rs1333049 of CDKN2B-AS1 gene was likely to increase a 16% incidence rate of cerebrovascular disease (CD) among various populations (odds ratio 1.16, 95% confidence interval 1.08–1.25; p<0.0001, random-effect method). CONCLUSION: Our case-control study identified rs1333049 genotypes showed different association with the concentration of the LDL-C, HDL-C and TC in the HS patients. Meta-analysis supported the association between rs1333049 and CD risk in various populations, although we were unable to observe association between rs1333049 and the risk of HSs in Han Chinese.
