The Serum Levels of Resistin and Its Relationship with Other Proinflammatory Cytokines in Patients with Alzheimer's Disease.
- Author:
Seden DEMIRCI
1
;
Ayşe AYNALI
;
Kadir DEMIRCI
;
Serpil DEMIRCI
;
Buket Cicioğlu ARIDOĞAN
Author Information
- Publication Type:Original Article
- Keywords: Resistin; Inflammatory cytokines; Alzheimer disease; Inflammation
- MeSH: Alzheimer Disease*; C-Reactive Protein; Cognition; Cytokines*; Humans; Inflammation; Interleukin-18; Interleukin-6; Interleukins; Resistin*; Tumor Necrosis Factor-alpha
- From:Clinical Psychopharmacology and Neuroscience 2017;15(1):59-63
- CountryRepublic of Korea
- Language:English
- Abstract: OBJECTIVE: The present study aims to analyze the levels of resistin, tumor necrosis factor alpha (TNF-α), interleukin (IL)-1β, IL-6, IL-18, and C-reactive protein (CRP) in patients with Alzheimer's disease (AD) and also investigate a potential relationship between resistin levels and TNF-α, IL-1β, IL-6, IL-18, and CRP levels in patients with AD. METHODS: The study included fifty patients with AD and 30 healthy controls with normal cognitive functions. The serum resistin, TNF-α, IL-1β, IL-6, IL-18, and CRP levels were assessed. We performed a Mini-Mental State Examination (MMSE) to evaluate the general cognitive performance. RESULTS: The mean serum resistin, IL-1β, IL-18, and TNF-α levels were significantly higher in patients with AD compared with the controls (p=0.026, p=0.002, p=0.003, and p=0.038, respectively). The IL-6 and CRP levels did not differ between the groups (p=0.874 and p=0.941). The resistin levels were positively correlated with the levels of CRP and IL-18 (r=0.526, p<0.001; r=0.402, p=0.004, respectively). MMSE scores and inflammatory markers were not correlated (p>0.05 for all). CONCLUSION: Serum resistin levels were significantly increased and correlated with some inflammatory markers in AD patients, suggesting that resistin might play a role in the inflammatory process of AD.
