Disulfiram Induced Psychosis.
- Author:
Satyakam MOHAPATRA
1
;
Nihar Ranjan RATH
Author Information
- Publication Type:Case Report
- Keywords: Disulfiram; Psychosis; Side effect
- MeSH: Alcoholism; Disulfiram*; Dopamine; Humans; Metabolism; Norepinephrine; Psychotic Disorders*
- From:Clinical Psychopharmacology and Neuroscience 2017;15(1):68-69
- CountryRepublic of Korea
- Language:English
- Abstract: Disulfiram is the commonly prescribed drug for the treatment of alcohol dependence. It's major metabolite (diethyldithiocarbamate) is an inhibitor of dopamine-betahydroxylase, an enzyme that catalyzes the metabolism of dopamine to norepinephrine resulting in psychosis. We recommend that disulfiram should be used at the lowest effective dose, possibly 250 mg daily and caution should be taken while prescribing disulfiram for patients with personal and familial antecedents of psychosis.
