The study on molecular evolution of influenza virus B isolated in Shenzhen from 1994 to 2006
10.3760/cma.j.issn.0254-5101.2011.05.003
- VernacularTitle:1994-2006年深圳市分离的B型流感病毒分子进化研究
- Author:
Chunli WU
;
Xiaowen CHENG
;
Xing Lü
;
Shisong FANG
;
Xin WANG
- Publication Type:Journal Article
- Keywords:
Influenza virus B;
Phyletic evolution;
Molecular mutation 25627964
- From:
Chinese Journal of Microbiology and Immunology
2011;31(5):398-402
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the prevalence and variation of influenza B viruses of Shenzhen. Methods Fifty strains influenza B viruses in Shenzhen from 1994 to 2006 were selected. HA1 gene were amplified by RT-PCR and sequenced. Phylogenetic analysis of HA1 was conducted by MEGA program. Results The influenza B viruses of Shenzhen were divided into Yamagata and Victoria lineage. The two lineages prevailed respectively in different years from 1994 to 2006. The variance of glycosylation site and some mutations of antigenic determinants were detected in the two lineages. Conclusion The viruses of Yamagata and Victoria lineage prevailed respectively in different years in Shenzhen but the mutation rates of the two lineages were slowly.
