Mania in Wolfram's Disease: From Bedside to Bench.
- Author:
Seshadri Sekhar CHATTERJEE
1
;
Sayantanava MITRA
;
Salil Kumar PAL
Author Information
- Publication Type:Case Report
- Keywords: Wolfram syndrome; Bipolar Disorder; Comorbidity
- MeSH: Affective Symptoms; Bipolar Disorder*; Comorbidity; Psychotic Disorders; Schizophrenia; Wolfram Syndrome
- From:Clinical Psychopharmacology and Neuroscience 2017;15(1):70-72
- CountryRepublic of Korea
- Language:English
- Abstract: Wolfram syndrome is a relatively unexplored entity in clinical psychiatry. Historically, the discovery of a specific WFS1 gene had generated huge fanfare regarding specific genetic causations of psychiatric disorders. While the initial enthusiasm has faded now, association of Wolfram syndrome with psychiatric illnesses like schizophrenia, psychosis and suicidal behavior still remain important for understanding biological underpinnings of such disorders. We report a case of Wolfram syndrome presenting with multiple manic episodes, discuss possible genetic underpinnings for the affective symptoms and then discuss certain issues regarding management.
