Research on the association of TIRAP coding region polymorphism with susceptibility to tuberculosis in Chinese Han population
10.3760/cma.j.issn.0254-5101.2011.06.006
- VernacularTitle:中国汉族人群TIRAP基因编码区多态性与结核病易感性的相关性研究
- Author:
Song LI
;
Nanying CHE
;
Zhixin DING
;
Xuxia ZHANG
;
Jun CHENG
;
Linbo ZHANG
;
Guangli SHI
;
Jie ZHANG
;
Xueyu WANG
;
Chuanyou LI
- Publication Type:Journal Article
- Keywords:
Tuberculosis;
Toll-interleukin 1 receptor domain containing adaptor protein;
Susceptibility;
Single nucleotide polymorphisms
- From:
Chinese Journal of Microbiology and Immunology
2011;31(6):502-506
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect specific polymorphisms in Toll-interleukin 1 receptor domain containing adaptor protein(TIRAP) coding region for Chinese Han population, and verify whether they are associated with susceptibility to tuberculosis. Methods Search TIRAP polymorphisms by sequencing in small sample; detect single nucleotide polymorphism(SNP) by ligase detection reaction technique in large sample; analyze whether polymorphisms are related to tuberculosis by statistic methods. Results Four polymorphisms were present in the TIRAP coding region. 394A had higher frequencies in the tuberculosis(TB)group than the control. But allelic and genotypic analysis showed that there were no significant difference in statistic between TB patients and controls(P>0.05). The SNP G164A mutation related with TB patient's condition. Comparing to controls, retreatment patients' allelic frequencies had significant difference in statistic(P<0.05), sputum positive patients and lung cavitation patients had lower 164A frequencies. Conclusion TIRAP coding region polymorphisms may be risk factors for TB occurrence and development in Chinese Han population.
