The changes of Th17, Tr cells and IL-17 in the process of antiviral treatment of Hunan AIDS patients
10.3760/cma.j.issn.0254-5101.2011.06.009
- VernacularTitle:湖南艾滋病患者Th17和Tr细胞及IL-17在抗病毒治疗过程中的变化
- Author:
Jing LI
;
Yan HE
;
Yuhuang ZHENG
;
Huaying ZHOU
;
Zi CHEN
;
Xia CHEN
;
Yan LUO
;
Yunhai YAO
;
Mei HE
- Publication Type:Journal Article
- Keywords:
AIDS;
HIV;
Th17 cell;
IL-17;
HAART
- From:
Chinese Journal of Microbiology and Immunology
2011;31(6):512-516
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the Th17, IL-17 and Tr cells equilibrium state as well as their changes of HIV infected or AIDS suffered patients in one-year HAART treatment. Methods Select 33 HIV/AIDS patients received HAART treatment while 33 healthy volunteers as controls. Flow cytometry was used to analyze Th17 and Tr cells in venous blood at the time of pre-therapy, 6th, 12th month when IL-17 levels in serum are tested by ELISA. Results The ratio of Th17 cells in CD4 cells in HIV/AIDS patients and volunteers were (1.20±0.37)%, (2.50±1.03)%, (3.70±1.56)%, (4.70±1.43)%, respectively; The ratio of Tr cells were (9.16±3.33)%, (7.19±2.91)%, (5.53±1.88)%, (4.43±0.97)%, respectively; The levels of IL-17 in serum were (5.3±2.5) pg/ml, (7.7±2.4) pg/ml, (10.4±3.1) pg/ml, (17.7±6.6) pg/ml respectively. The Th17 cells' level was positively correlative with the amount of CD4 cells, negatively correlate with the count of viral load. However, the Tr cells level is positively correlative with the count of viral load, negatively relate to the quantity of CD4 cells. Conclusion HIV could make IL-17, Th17 cells and Tr cells lost their balance, but the immune equilibrium state may gradually recover after HAART treatment. Which indicates the IL-17, Th17 cells and Treg cells may play an important role in the pathogenesis of AIDS, and they are likely to be the effective indexes to observe the progress of AIDS and the treatment effect of highly active antiretroviral therapy(HAART).
