Unbalance and involvement of Th17/Tr cells in patients with cervical cancer

VernacularTitle:宫颈癌患者癌组织中Th17/Tr细胞明显升高与疾病进程相关
Author: Ting FU ; Peifang YANG ; Zhijun JIAO ; Jianxin ZHANG
Publication Type:Journal Article
Keywords: Cervical cancer; Th17 cells; Tr cells
From: Chinese Journal of Microbiology and Immunology 2011;31(4):312-315
CountryChina
Language:Chinese
Abstract: Objective To detect the levels of Th17 and regulatory T(Tr)cells in Imripheral blood mononuclear and tumor tissue from patients with cervical cancer and analyze the relationship hetween Th17 and Tr cells in cervical cancer progression.In addition.the significance of the Th17/Tr cells ratio in cervical cancer pathogenesis was discussed.Methods The expression levels of Th17 and Tr cells were determined by flow cytometry from 32 patients with cervical cancer and 15 health people.The mechanism of involvement of Th17 and Tr cells proportionality in cervical cancer pathogenesis and the correlation between Th17 and Trwas assessed by bivariate correlation analysis.Results The expression levels of both Th17 and Tr in patients were higher than control groups,especially in late stage patients Th17 and Tr proportionality lower than early group,and there was a negative correlation between them.Conclusion Th17 and Tr cells proportionality may be involve in the development of cervical cancer so as to provide novel strategies for tumor immunotherapy.