Impact of the new CKD-EPI equation on the staging of patients with chronic kidney disease based on abbreviated MDRD equation
10.3760/cma.j.issn.1001-7097.2011.05.010
- VernacularTitle:CKD-EPI方程对基于简化MDRD方程的慢性肾脏病患者分期的影响
- Author:
Jiangtao LI
;
Chen XU
;
Chunli CUI
;
Huifang WANG
;
Yitai WU
;
Aihong YUAN
;
Xiaofeng JIANG
;
Jun MA
- Publication Type:Journal Article
- Keywords:
Kidney disease,chronic;
Glomerular filtration rate;
Chronic kidney disease epidemiology collaboration equation;
Abbreviated modification of diet in renal disease study equation
- From:
Chinese Journal of Nephrology
2011;27(5):346-350
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the estimated CFR (eCFR) values using the new chronic kidney disease epidemiology collaboration (CKD-EPI) equation with those from the abbreviated MDRD equation in a Chinese cohort with chronic kidney disease (CKD) and to analyze the impact of the new CKD-EPI equation on the staging of CKD. Methods A total of 450 Chinese patients (239 female and 211 male) with CKD were enrolled. eCFRs obtained by the CKD-EPI equation and the abbreviated MDRD equation were compared with the Bland and Altaian method. The agreement between two equations in CKD staging was assessed by Kappa test. Results Mean eGFR was 2.4 ml ·(min)-1 ·( 1.73 m2)-1 higher with the CKD-EPI equation as compared to the abbreviated MDRD equation. The percentage of CKD staging concordance between equations for stage 1, 2, 3A, 3B, 4, and 5 was 97.10% (n=67), 80.77% (n=105), 6 0.86% (n= 48), 87.69%(n=57), 90.38% (n=47) and 98.18% (n=54) respectively. Kappa index was 0.913 (95%C/: 0.881-0.945). The CKD-EPI equation reclassified 19.23% (n=25) and 39.24% (n=31) of patients with CKD stage 2 and 3A,upward to a higher eCFR category. Conclusions The new CKD-EPI equation reclassifies a number of patients to higher CKD stages, especially those classified as CKD stage 2 or 3A by the abbreviated MDRD equation.
