Association between polymorphisms of PlARK16 gene and susceptibility to Parkinson's disease in Chinese Han population
10.3760/cma.j.issn.1006-7876.2011.05.013
- VernacularTitle:中国汉族人群PARK16基因多态性与帕金森病易患性的关联
- Author:
Yanyan ZHAO
;
Xingjian LIN
;
Weiguo LIU
;
Min YE
;
Jiechun CHEN
;
Shouyong WANG
;
Hong XIAO
- Publication Type:Journal Article
- Keywords:
Parkinson disease;
Casein kinase Ⅱ;
Cyclin-dependent kinases;
Polymorphism,single nucleotide;
Genetic perdisposition to disease;
Polymerase chain reaction
- From:
Chinese Journal of Neurology
2011;44(5):343-346
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between PARK16 gene polymorphism and Parkinson's disease(PD)susceptibility in Chinese Han population.and to analyze its single-nucleotide polymorphism(SNP)genotypes,frequencies and odds ratios(OR)of different genotypes.Methods The association between two SNP loci in PARK16 gene(Rs947211,Rs823128)and PD susceptibility was investigated by TaqMan quantitative polymerase chain reaction(PCR)in 226 PD patients and 362 healthy controls.Allele and genotype frequencies were calculated by the Chi-square test,and the clinical data were also analyzed.Results Three genotypes of Rs947211(GG,AG and AA)account for 34.1%(77/226),46.0%(104/226),19.9%(45/226)in the PD group,and 23.8%(86/362),53.0%(192/362),23.2%(84/362)in the control group,respectively.There was significant difference between two groups (P<0.05).Setting the GG genotype as the reference,OR values of AG and AA genotype were 0.57(95%CI0.38-0.85,P=0.006)and 0.55(95%CI 0.34-0.85,P=0.015),while the OR value for exposure to the A allele(AA+AG)was 0.56(95%CI0.38-0.82,P=0.003).Genotypes of Iate-onset PD were also significantly different from the controls(OR valne of AG=0.46,95%CI 0.27-0.78,P=0.004:OR value of AA=0.35.95%CI 0.18-0.68,P=0.002).And there was no diffefence in clinical features among the 3 genotypes. The frequency of Rs823128, another locus, in PD group was not significantly different from the control group( AA genotype as the reference, OR value of AG was 1. 12, 95% CI 0. 75-1.68, P = 0.568; OR value of GG was 0.99, 95% CI 0.35-2.76, P = 0.994). Conclusion Polymorphism of PARK 16 locus Rs947211 is associated with PD patients in Chinese Han population.
