Association of serum osteoprotegerin levels with bone mineral density and bone turnover markers in patients with hyperthyroidism before and after methimazole treatment
10.3760/cma.j.issn.1671-7368.2011.05.024
- VernacularTitle:甲状腺功能亢进症治疗前后血清护骨素水平的变化及与骨密度和骨转换指标的关系
- Author:
Shentian WANG
;
Liang LI
;
Chunyuan ZHANG
;
Wen RONG
;
Li CHEN
- Publication Type:Journal Article
- Keywords:
Hyperthyroidism;
Osteoprotegerin
- From:
Chinese Journal of General Practitioners
2011;10(5):354-355
- CountryChina
- Language:Chinese
-
Abstract:
Serum bone alkaline phosphatase (BAP) , osteocalcin (OC) , C-telopeptides of type-1 collagen (CTx) , osteoprotegerin (OPG) levels, and bone mineral density (BMD) were evaluated in 62 hyperthyroid patients and 60 healthy subjects matched for sex and age. In hyperthyroid patients, the biochemical evaluations and bone density were performed before and after 6 months of methimazole ( MMI) treatment. Results showed that the BMD in lumbar spine L2 - L4, neck of femur, Ward's triangle and greater trochanter of patients before treatment were all significantly lower than those in healthy controls, and improved markedly after MMI treatment. The serum bone turnover parameters BAP, OC and CTx in patients before treatment were all significantly higher than those in control group, and were decreased markedly after treatment. The serum OPG level in patients with hyperthyroidism was significantly higher than that in healthy controls, and decreased markedly after treatment. The serum OPG levels were significantly correlated with bone turnover parameters ( BAP, OC, CTx) and BMD, which indicates that serum OPG level can reflect the abnormality of bone metabolism in patients with hyperthyroidism.
