Early clinical features of severe cases with hand-foot-mouth disease

VernacularTitle:手足口病重症病例的早期临床特征分析
Author: Zhenwu YAN ; Jianhong CHEN ; Shuhua LI ; Haiying GAO ; Wanpeng WANG ; Xianjie YU
Publication Type:Journal Article
Keywords: Hand,foot and mouth disease; Diagnosis
From: Chinese Journal of General Practitioners 2011;10(5):343-345
CountryChina
Language:Chinese
Abstract: The clinical features of 120 severe cases with hand-foot-mouth disease (HFMD) were retrospectively analyzed compared with those of the regular cases. Clinical data showed that the age of mostsevere cases ranged from 1-3 years. Sustained high fever ( 55% ) , hypertension ( 40% ) , fewer rash (73.3%) were important clinical features. Lethargy, somnolence or restlessness (70. 8% ), vomiting (30. 8% ) were early signs of central nervous system ( CNS) ; and the CNS involvement in severe cases was characterized by body trembling or muscle spasm (80% ). High white cell count(75. 8% ) and high blood glucose levels(32. 5% ) were important makers to diagnose the severe HFMD at early stage. There were significant differences in presentation of above features between severe cases and regular cases of HFMD ( P < 0. 01 or P < 0. 05 ) . Early treatment with mannitol, gamma globulin and glucocorticoids were effective, no death was reported and no side effects were found in this case series.