Investigation of a cognitive function impairment and its related factors in elderly patients with subclinical hypothyroidism
10.3760/cma.j.issn.0254-9026.2011.07.011
- VernacularTitle:老年亚临床甲状腺功能减退症患者认知功能障碍及相关因素分析
- Author:
Ping LU
;
Quane KAN
;
Jianxin MA
;
Ju YUAN
- Publication Type:Journal Article
- Keywords:
Hypothyroidism;
Cognition disorders
- From:
Chinese Journal of Geriatrics
2011;30(7):566-568
- CountryChina
- Language:Chinese
-
Abstract:
Objective To understand the features of cognitive impairment in patients with subclinical hypothyroidism. Methods The cognitive function of the patients with subclinical hypothyroidism and the healthy controls was tested using Mini-Mental State Examination (MMSE) and Wechsler Memory Scale (WMS). The change in cognitive function was observed and analyzed before and after L-T4 treatment. Results Fifty-seven patients with subclinical hypothyroidism and the same number of healthy controls were enrolled in this study. There were no significant differences between two groups in biochemical indexes and MMSE score (all P＞0.05). But there were significant differences between two groups in WMS score, including pictures, memories, learning, touch, understanding memory and back several test scores (all P＜0.05). There existed certain degree of cognitive dysfunction mainly displayed in memory, attention, etc. After three months of L-T4 treatment, all had significant improvement (all P＜0.05). Conclusions Patients with subclinical hypothyroidism have cognitive dysfunction, when the thyroid stimulating hormone is restored to normal level, cognitive function is also improved.
