Association study of interleukin-1 genotypes with Alzheimer′s disease

VernacularTitle:白细胞介素1基因型与阿尔茨海默病的相关性研究
Author: Jingjing YAO ; Zheng WANG ; Lan CHEN ; Shurong HE ; Huiyan YU ; Fang FANG ; Li YANG ; Xubai QIAO ; Wei ZHANG ; Jun DU ; Bin QIN ; Dongge LIU
Publication Type:Journal Article
Keywords: Alzheimer disease; Interleukin-1; Genotype; Polymorphism,restriction fragment length
From: Chinese Journal of Geriatrics 2011;30(7):533-536
CountryChina
Language:Chinese
Abstract: Objective To explore the association of interleukin (IL)-1 genotypes with Alzheimer′s disease (AD). Methods Using polymerase chain reaction and restriction fragment length polymorphism, the IL-1A (-889) and IL-1B (+3953) genotypes in 84 cases of AD and 139 controls were detected and analyzed. Results The frequencies of IL-1A(- 889) C/C, C/T and T/T genotypes were 72.6% and 84.2%, 23.8% and 14.4%, 3.6% and 1.4% in AD cases and controls respectively. The genotypes frequencies of IL-1A (-889) C/C, C/T and T/T in AD cases were similar to that of controls (χ2=4.53, P＞0.05), but the frequencies of IL-1A (-889) T allele were significantly higher in AD cases than in controls (15.5% vs. 8.6%, χ2=4.93, P＜0.05). The frequencies of IL-1B (+3953) C/T genotypes and T allele were also significantly higher in AD cases than in controls (16.7% vs. 6.5%, 8.3% vs. 3.2%, χ2=5.88,5.56, both P＜0.05). Conclusions IL-1 genotypes are associated with AD. IL-1 genotypes may play an important role in the development of AD.