Efficacy and safety of two kinds of homemade sirolimus-eluting stents for treatment of acute ST segment elevation myocardial infarction
10.3760/cma.j.issn.0254-9026.2011.07.006
- VernacularTitle:两种国产西罗莫司洗脱支架治疗ST段抬高型心肌梗死患者的疗效和安全性研究
- Author:
Jide LU
;
Jianping QIU
;
Jie LIN
;
Yu HUANG
;
Hairong WANG
;
Maochun XU
;
Guizhen DOU
;
Peiying WU
- Publication Type:Journal Article
- Keywords:
Myocardial infarction;
Angioplasty,transluminal,percutaneous coronary;
Stent
- From:
Chinese Journal of Geriatrics
2011;30(7):547-550
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the efficacy and safety of two kinds of homemade sirolimus-eluting stents (Firebird and Excel) for treatment of acute ST segment elevation myocardial infarction (STEMI) in patients who underwent percutaneous coronary intervention (PCI). Methods The 249 consecutive patients with STEMI who underwent PCI were randomly divided into two groups: Excel group (n=136) and Firebird group (n=113). They were followed up for 6-24 months, and coronary angiography was reviewed average 12 months later. The primary endpoints were major adverse cardiac events, including death, reinfarction and target vessel revascularization. The second endpoints included late luminal loss and restenosis 12 months after treatment. Results There were no significant differences in baseline data, coronary arterial lesion before operation, and immediateness condition after PCI between the two groups (all P＞0.05). Within follow-up, there were 2 (1.47%) death cases and 1 (0.88%) death case, 1 (0.74%) and 1 (0.88%) nonfatal myocardial infarction case, 2 (1.47%) and 2 (1.77%) target vessel revascularization cases in the two groups respectively (all P＞0.05). There were no significant differences in late luminal loss of in-stent and in-segment, the rates of in-stent restenosis, in-segment restenosis and stent thrombosis, the in-stent minimal lumen diameter and in-segment minimal lumen diameter between the two groups (all P＞0.05). Conclusions The two kinds of homemade sirolimus-eluting stents may have similar efficacy and safety in patients with STEMI treated with primary PCI.
