Investigation of the influence of different etiologies on serum level of carbohydrate antigen 125 in elderly patients with heart failure
10.3760/cma.j.issn.0254-9026.2011.06.007
- VernacularTitle:不同病因对老年心力衰竭患者血清CA125水平的影响
- Author:
Qi HUANG
;
Mingbin XIE
;
Min WANG
;
Zhengming XU
;
Dean PEI
;
Qiang YAO
;
Ronghua LUO
;
Shien HUANG
;
Shisheng WANG
- Publication Type:Journal Article
- Keywords:
Heart failure,congestive;
CA-125 antigen;
Natriuretic peptide,brain
- From:
Chinese Journal of Geriatrics
2011;30(6):464-466
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of different etiology on the serum level of carbohydrate antigen 125 (CA125) in elderly patients with chronic congestive heart failure (CHF), and to assess any correlation of CA125 with serum level of B-type natriuretic peptide (BNP). Methods The 155 aged patients with New York Heart Association (NYHA) class Ⅲ or Ⅳ were enrolled and grouped into four reasons of hypertension, coronary heart disease (CHD), cardiomyopathy and other reasons, and 25 healthy old persons as control.CA125 and BNP levels were measured by automatic chemiluminescent immunoassay and enzyme immunoradiometric assay, respectively. Results CA125 level in patients with CHF was (83.4±6.6)U/L for hypertension, (36.8±1.4)U/L for CHD, (38.1±1.6)U/L for cardiomyopathy and (38.4±1.4)U/L for other reasons, which significantly higher than for healthy controls [(14.3±1.15) U/L, P＜0.05].Especially, CA125 level in hypertension group was notable higher than in other reasons of group (P＜0.05), and was positively related to BNP level (r=0.67,P＜0.05). Conclusions Serum CA125 level is a predictor for clinical pathogen of CHF.Therefore, it may be a useful additional marker for the evaluation of clinical treatment of these patients
