Insulin-like growth factor-I and II and insulin-like growth factor binding protein-3 in amniotic fluid at second trimester: A correlation with birth weight.
- Author:
Ji Young KIM
1
;
Soon Ha YANG
;
In Sik LEE
Author Information
1. Department of Obstetrics and Gynecology, School of Medicine, Sungkyunkwan University, Samsung Medical Center.
- Publication Type:Original Article
- Keywords:
Insulin-like growth factor;
Insulin-like growth factor binding protein;
Amniotic fluid;
Birth weight
- MeSH:
Amniotic Fluid*;
Birth Weight*;
Female;
Humans;
Infant, Newborn;
Insulin-Like Growth Factor Binding Protein 3;
Insulin-Like Growth Factor I;
Insulin-Like Growth Factor II;
Linear Models;
Parturition*;
Pregnancy;
Pregnancy Trimester, Second*;
Radioimmunoassay
- From:Korean Journal of Obstetrics and Gynecology
2001;44(4):668-673
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: o determine the correlation between birth weight and the level of insulin-like growth factor(IGF)-I, -II and insulin-like growth factor binding protein(IGFBP)-3 in amniotic fluid at second trimester and to evaluate possibility whether the levels of IGF-I, II and IGFBP-3 could predict birth weight. METHODS: Sixty-seven samples of amniotic fluid in second trimester were analyzed for IGF-I, IGF-II, and IGFBP-3 by radioimmunoassay. Newborn birth weights were stratified arbitrarily as <25th percentile, 25-75th percentile, and >75th percentile. Linear regression analysis and Kruskal-Wallis test were used in well appropriately for statistical analysis. RESULTS: The level of IGF-I showed positive correlation with birth weight. However, the levels of IGF-II and IGFBP-3 showed no significant correlation with birth weight. The level of IGF-I were signifi cantly different among these groups. However, the levels of IGF-II and IGFBP-3 were not significantly different among these groups divided by the birth weight percentile. CONCLUSION: The levels of IGF-I in amniotic fluid at second trimester may be useful marker in predicting birth weight.
