Effect of myocardial function in diabetic rats with early insulin treatment
10.3760/cma.j.issn.1004-4477.2011.06.021
- VernacularTitle:早期胰岛素治疗对糖尿病大鼠心肌功能的干预作用
- Author:
Jun ZHANG
;
Yunyan DUAN
;
Bin MA
;
Jianguo HE
;
Haili SU
;
Liwen LIU
;
Minjuan ZHENG
;
Ting ZHU
;
Hongling LI
- Publication Type:Journal Article
- Keywords:
Echocardiography;
Diabetes mellitus;
Insulin;
Ventricular function
- From:
Chinese Journal of Ultrasonography
2011;20(6):524-527
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the myocardial function with early insulin treatment by velocity vector imaging (VVI) combined with dipyridamole stress in diabetic rats.Methods The 30 rats comprised 20 diabetic rats and 10 normal rats in the study.The 20 diabetic rats were divided into the diabetes mellitus(DM) group and the treatment group.Every rat in the treatment group was hypodermic injected with protamime biosynthetic human insulin after the diabetic model established.The control group was including 10 normal rats of the same age.After 8 weeks,each rat was performed with VVI at baseline and after dipyridamole stress.Results At baseline VVI,the parameters in the DM and the treatment groups were reduced compared with those in the control group.The systolic velocity,circumferential strain,systolic and diastolic circumferential strain rate in the treatment group were increased significantly compared with those in the DM group.After stress,the VVI reserve parameters in the treatment group were higher than those in the DM group.Conclusions The myocardial function are improved with early insulin treatment in the diabetic rats.
