Effect of magnesium isoglycyrrhizinate on liver cirrhosis of decompensated stage
10.3760/cma.j.issn.1008-6315.2011.05.004
- VernacularTitle:异甘草酸镁治疗失代偿期肝硬化的疗效观察
- Author:
Guohua TIAN
;
Guoshun ZHANG
;
Yulan WANG
;
Xuejun ZHANG
;
Ning MA
- Publication Type:Journal Article
- Keywords:
Liver cirrhosis;
Magnesium isoglycyrrhizinate;
Compound ammonium glycyrrhetate
- From:
Clinical Medicine of China
2011;27(5):458-460
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the curative effect of magnesium isoglycyrrhizinate and compound ammonium glycyrrhetate in patients with liver cirrhosis of decompensated.Methods Eighty-six patients with liver cirrhosis of decompensated were enrolled into the study and randomly divided into two groups: the treatment group(n=43) were given magnesium isoglycyrrhizinate once a day in addition to routine treatment;the control group(n=43) were given compound ammonium glycyrrhetate once a day in addition to routine treatment.The clinical manifestation,including symptoms,signs and hepatic function were observed.The clinical lab data,including blood routine examination,urine routine test and kidney function of all patients from two groups were collected before and after the treatments.The adverse drug reactions were monitored throughout the whole therapy.Results ALT and AST turned to normal in 97.7%(42/43) and 90.7%(39/43) of patients respectively in the treatment group,which were significantly higher than those of 72.1%(31/43) and 74.4%(32/43) respectively in the control group( x2=9.86 and 4.73,respectively,Ps＜0.05). Time to turning to normal in ALT and AST were(21.6±9.1)d and(23.1±10.6)d in the treatment group,which were significantly lower than those of(37.5±17.8)d,and(46.7±19.4)d respectively in the control group(t=5.23 and 7.01,respectively,Ps＜0.01).Conclusion The results suggested that magnesium isoglycyrrhizinate had better effect on alleviating symptoms and decreasing enzyme in treatment of liver cirrhosis of decompensated stage.
