Study on blood lipoprotein(a) in patients with essential hypertension and coronary heart disease
10.3760/cma.j.issn.1008-6315.2011.05.008
- VernacularTitle:原发性高血压合并冠心病患者脂蛋白(a)的变化
- Author:
Jing ZHANG
;
Luosha ZHAO
;
Min GAO
;
Fan YANG
;
Jiangchuan DU
;
Yang LI
- Publication Type:Journal Article
- Keywords:
Essential hypertension;
Lipoprotein(a);
Coronary heart disease;
Risk factor
- From:
Clinical Medicine of China
2011;27(5):471-474
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the changes of lipoprotein(a)[LP(a)] in patients with essential hypertension(EH) and coronary heart disease(CHD).Methods One hundred and fifty-nine EH older patients were recruited in the study.Eighty-six elderly patients were diagnosed as EH combined with CHD,and 73 patients were diagnosed as simple EH.All patients were tested for the fasting blood glucose(FBG),creatinine(Cr),total cholesterol(TC),triglyceride(TG),HDL-C,LDL-C,LP(a),and the body mass index(BMI) was calculated.Results Plasma Lp(a) increased(0.48±0.18)mmol/L in the EH combined with CHD patients,which were significantly higher than the increasing of(0.34±0.12) mmol/L in the simple EH patients(t=-11.367,P＜0.05).The level of plasma Lp(a) increased with the severity of the stenosis of the coronary artery(Lp(a):(0.37±0.14) mmol/L in single arterial branch stenoses,(0.46±0.15)mmol/L in double arterial branch stenoses,(0.66±0.12)mmol/L in triangle arterial branch stenoses,F=31.842,P=0.012).Conclusion The Lp(a) concentration in patients with EH are correlated with the occurrence and severity of coronary heart disease.As a risk of coronary heart disease,Lp(a) can predict the severity of coronary artery stenosis.
