Association study between polymorphism of tumour necrosis factor-α-863 and gout

VernacularTitle:肿瘤坏死因子-α-863位点基因多态性与痛风相关性的初步研究
Author: Yuhong JIA ; Liufu CUI ; Wenhao YANG ; Rong SHU ; Haicheng SONG ; Yixuan HAN ; Ping YU ; Jian WANG ; Jierui WANG
Publication Type:Journal Article
Keywords: Gout; Gene polymorphism; Tumour necrosis factor-α
From: Clinical Medicine of China 2011;27(5):485-487
CountryChina
Language:Chinese
Abstract: Objective To investigate the association between the tumour necrosis factor-α-863(TNF-α-863) polymorphism and gout in Han population from the city of Tangshan.Methods We recruited 80 gout patients and 80 healthy individuals into this study.The polymorphisms of TNF-α-863 site were analyzed by polymerase chain reaction-ligase detection reaction(PCR-LDR).The frequencies of different TNF-α-863 genotypes/alleles were analyzed in the gout group and the control subjects.Results No significant differences were observed in the genotype frequencies(x2=2.8807,P=0.0897) and allelic frequencies(x2=4.2646,P=0.1187) of TNF-α-863 site in the comparison between gout and control groups.Conclusion The result of our study suggests that the polymorphism of TNF-α-863 site may not related to gout in Han population in Tangshan.