Danshen injection affecting NGF positive cells after traumatic brain injury in rats by fluid percussion

VernacularTitle:丹参对大鼠液压脑损伤后神经生长因子表达的调节作用
Author: Pingan LI ; Xiaolin LUO ; Yingjiao YU ; Jianxiang LIU ; Biao ZHU ; Jing LI ; Yandong ZHONG ; Zongli HU
Publication Type:Journal Article
Keywords: SALVIA MILTIORRHIZA△/PD; Brain injuries/ZD/ME; Nerve growth factor/ME/DE
From: Journal of Chinese Physician 2011;13(4):461-463
CountryChina
Language:Chinese
Abstract: Objective To study on NGF positive cells changes by the action of Danshen and explore the correlation between time and amount of NGF after traumatic brain injury (TBI)in rat.Methods72 rats were randomly divided into 3 groups,including sham group,brain injury and Danshen therapy group.TBI rat models were made by fluid percussion.NGF was determined on the 3rd,7th and 14th day after TBI.ResultsNGF positive cells after traumatic brain injury in brain reached the maximum level at the 3rd day(1.29±0.61),and it decreased since the 7th day(2.03±0.42),and it decreased to the lowest level on the 14th day (0.87±0.23).NGF positive cells after traumatic brain injury treated by Danshen were more than those patients who were treated without Danshen(1.77±0.54,3.35±0.37,0.65±0.21 vs 0.75±0.31,1.58±0.52,0.49±0.36,P＜0.05～0.01).ConclusionsThe expression of NGF was significantly increased in brain damaged tissues.This may be served as a useful marker of diagnosis in time-course of brain leison.Danshen injection can be used to protect brain after traumatic brain injury.