The experimental research anti-tumor effect of modified decoction for driving out blood stasis in the blood mannsion
10.3760/cma.j.issn.1673-4246.2011.05.006
- VernacularTitle:加味血府逐瘀汤对H22移植性肿瘤小鼠抗肿瘤作用的研究
- Author:
Yan LI
;
Zhonglong MA
;
Wei TIAN
;
Hui LIU
- Publication Type:Journal Article
- Keywords:
Modified Decoction for Driving Out Blood Stasis in the Blood Mannsion;
H22 mice model;
VEGF;
life extension rate;
inhibition rate of tumor
- From:
International Journal of Traditional Chinese Medicine
2011;33(5):405-407
- CountryChina
- Language:Chinese
-
Abstract:
Objective Modified Decoction for Driving Out Blood Stasis in the Blood Mannsion on ascites tumor model of transplanted H22 anti-tumor effect and the impact of VEGF. Methods Adult male mice 100, inoculated with H22 hepatoma cells, the establishment of ascites H22 transplanted tumor model, then divided into 10 groups were given saline, capecitabine, flavored Modified Decoction for Driving Out Blood Stasis in the Blood Mannsion (high, medium and low dose) was administered orally for 10 days, 11 days of treatment, observation of suppression tumor rate, the rate of change in life extension; detected by immunohistochemistry the expression of VEGF in tumors, SPSS13.0 software for statistical analysis. Results Capecitabine, flavored Xuefuzhuyutang (high, medium and low dose) inhibited tumor growth rates were 60%, 49%, 41%, 35%, life extension rate of the three groups were 1.68% 157.98%, 70.58%, 49.57% higher. Conclusion Modified Decoction for Driving Out Blood Stasis in the Blood Mannsion can inhibit tumor cell proliferation in tumor-bearing mice, significantly prolonged the survival time of mice, reduce the tumor tissue and tumor tissue expression of VEGF.
