Human leukocyte antigen and lung cancer
10.3760/cma.j.issn.1673-422X.2011.05.016
- VernacularTitle:人类白细胞抗原与肺癌
- Author:
Yang MEI
;
Hao PING
- Publication Type:Journal Article
- Keywords:
Lung neoplasms;
HLA antigens;
Tumor escape
- From:
Journal of International Oncology
2011;38(5):370-373
- CountryChina
- Language:Chinese
-
Abstract:
HLA (human leukocyte antigen) is critical molecule relevant to immunoresponse, which is always involved in antigen presentation and determining killing activity of immune cells against tumor. The abnormal expression of HLA in lung cancer is believed to be a common phenomena of tumor biology. It has been demonstrated that HLA expression varies in various types of lung cancer, even in differential stages of one type of lung cancer. HLA expression is highly associated with genre, progression and prognosis of lung cancer. The thorough investigations of the relationship between HLA and lung cancer and of mechanism of HLA abnormality will provide useful information for studying of development of lung cancer and tumor immunotherapy.
