Electrophysiological study on the modulation of uterine mechanoreceptor by substance P.
- Author:
Joong Yol NA
1
;
Ki Hoon CHANG
;
Jae Chul SHIN
;
Sang Wook YOU
;
Soon Choul HONG
;
Seo Eun LEE
;
Hee Chul HAN
Author Information
1. Department of Obstetrics and Gynecology, College of Medicine, Korea University, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Substance P;
Inflammatory hyperalgesia;
Uterine nerve fiber
- MeSH:
Animals;
Cats;
Hyperalgesia;
Inflammation;
Mechanoreceptors*;
Nerve Fibers;
Receptors, Neurokinin-1;
Substance P*;
Uterine Artery;
Uterus
- From:Korean Journal of Obstetrics and Gynecology
2001;44(4):740-747
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: In inflammation, hyperalgesia is a common phenomenon but its mechanism has not been clarified. Recently some reports suggested substance P might be important factors for inflammatory hyperalgesia in somatic tissue. This study was performed to see whether substance P modulate the activities of uterine afferent fibers in the hypogastric nerve of the cat. METHODS: While recording the electrical activities of nerve fibers, mechanical stimuli were applied as balloon distention using balloon inserted into uterine lumen before and during substance P infusion through uterine artery. RESULTS: Substance P increased the responses to balloon distension of uterus in 14 uterine mechanoreceptive afferent fibers of 24 over 10% compared to before substance P infusion, and decreased the responses of 3. And L-703,606, the neurokinin 1 receptor antagonist failed the modulation of mechano sensitive response by substance P and reduced the spontaneous activities. CONCLUSIONS: These results suggest that substance P modulated the activities of uterine nerve fibers and their responses to mechanical stimulus. It is hypothesized that this kind of modulation of afferent nerve fibers by substance P may be important for the development of inflammatory hyperalgesia.
