Marine algae polysaccharide derivant in treatment of osteoporosis in rats
10.3969/j.issn.1673-8225.2011.24.037
- VernacularTitle:海藻酸多糖衍生物治疗大鼠骨质疏松
- Author:
Yanli SI
;
Dongxia LI
;
Youcai LIU
;
Zhibin QIAN
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2011;15(24):4519-4521
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND: We have previously reported that marine algae polysaccharide derivant can significantly promote bone cell growth.OBJECTIVE: To observe the effect of marin algae polysaccharide derivant in treatment of osteoporosis.METHODS: Sixty female Wistar rats were randomly divided into control group, treatment group and model group. There were 20 rats in each group. The rats in treatment group and model group were respectively treated with retinoic acid to induce osteoporosis. The rats in treatment group were gavaged the marine algae polysaccharide derivant 10 mg/kg, and the rats in model group were gavaged the glucose 10 mg/kg orally for 14 days. Changes of rat femur bone histological examination and histomorphometry parameters were observed.RESULTS AND CONCLUSION: The mean Trabecular Number (Tb.N), the mean Trabecular Thickness (Tb.Th) and the percent Trabecular Area (Tb.Ar%) were significantly decreased in the model group compared with control group. The mean trabecular separation (Tb.Sp) was greatly increased. After intake of marine algae polysaccharide derivant, Tb.N, Tb.Th and Tb.Ar% of the treatment group were significantly more than that of the model group. The Tb.Sp was obviously reduced. These indicate that marine algae polysaccharide derivant can increase bone mass and have a therapeutic and preventional effect on the osteoporosis.
