Macrophage in tumor metastasis
10.3760/cma.j.issn.1673-422X.2011.05.006
- VernacularTitle:巨噬细胞与肿瘤转移
- Author:
Ru ZHOU
;
Yiming ZHOU
;
Zongyou CHEN
- Publication Type:Journal Article
- Keywords:
Neoplasms;
Macrophage;
Neoplasm metastasis
- From:
Journal of International Oncology
2011;38(5):338-342
- CountryChina
- Language:Chinese
-
Abstract:
There is persuasive clinical and experimental evidence that macrophages promote cancer initiation and malignant progression. The aggregation of macrophages indicates poor prognosis of tumor associated diseases. During tumor initiation, macrophages create an inflammatory environment that is mutagenic to cells and promotes cell growth; as tumors progressing, macrophages create premetastatic niche for the arriving tumor cells at premetastatic sites ; then macrophages provide critical nutrients for these initial metastatic tumor cells.Along with these great achievements in research of macrophage, it is believed that several novel directions of tumor therapy surely occur in the future.
