Progress on DAB2IP gene
10.3969/j.issn.1000-4718.2011.07.037
- VernacularTitle:DAB2IP 基因的研究进展
- Author:
Yan YUAN
;
Haibin CHEN
- Publication Type:Journal Article
- Keywords:
Genes,DAB2IP;
Genes,DAB2;
Gene regulation;
Methylation
- From:
Chinese Journal of Pathophysiology
2011;27(7):1445-1449
- CountryChina
- Language:Chinese
-
Abstract:
Human DAB2 interaction protein (DAB2IP) is a novel member of Ras GTPase-activating protein family. It interacts directly with disabled-2 protein (DAB2/DOC2) which suppresses growth of cancers derived from different tissues, including mammary, prostate and ovarian cancers. DAB2IP was identified as an immediate downstream effector mediated by DAB2/DOC2. DAB2IP and DAB2/DOC2 form a unique protein complex that has a negative regulatory effect on the Ras-mediated signal pathway. It is demonstrated that DAB2IP is a tumor suppressor gene inactivated by methylation in several cancers. This article reviews the structure and biological functions of DAB2IP gene as well as its potential roles in carcinogenesis and evolution.
