MicroRNA in platinum-resistance of ovarian cancer
10.3760/cma.j.issn.1673-422X.2011.05.020
- VernacularTitle:微小RNA与卵巢癌铂类耐药的研究进展
- Author:
Cheng YU
;
Lu XIN
- Publication Type:Journal Article
- Keywords:
MicroRNAs;
Ovarian neoplasmas;
Drug resistance,neoplasm
- From:
Journal of International Oncology
2011;38(5):384-386
- CountryChina
- Language:Chinese
-
Abstract:
MircoRNAs (miRNAs) are widely existing inorganisms, non-coding small RNA. MircoR-NAs play important role in cell proliferation, apoptosis, stress resistance and fat metabolism. In vitro studies indicate that miRNAs are important factors in platinum resistance of ovarian cancer cell lines. However, the pathway of platinum resistance of ovarian cancers is complex. Studies find miRNA expression play important roles in the sensitivity of platinum resistance of ovarian cancer cell lines , and can be used as an early alert for platinum resistance. Changing the expression of miRNA even can reverse the platinum resistance . But the regular role of miRNAs in target genes network is still unconfirmed. Thus, more studies about miRNA in vivo and animal tumor models are needed to identify the function of miRNAs in platinum resistance of ovarian cancer.
