Association of cytokine IL-10 levels with cachexia from patients with low-third gastric cancer
- VernacularTitle:血清IL-10水平与胃窦癌恶病质的关系
- Author:
Chunwei LI
;
Fengbo SUN
;
Dianliang ZHANG
;
Hongmei ZHENG
;
Bo SONG
- Publication Type:Journal Article
- Keywords:
Cytokine;
Gastric cancer;
Cachexia
- From:
Parenteral & Enteral Nutrition
2010;17(2):69-71
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the association of the serum levels of cytokine IL-10 with the occurrence of cachexia from patients with low-third gastric cancer. Methods: Radioimmunoassay was used to examine the serum levels of IL-10 in 150 patients with low-third gastric cancer and 135 healthy controls. Results: The serum levels of IL-10 were significantly higher in patients with low-third gastric cancer than controls(Z=-11.862, P<0.01). The serum levels of IL-10 were significantly higher in patients with low-third gastric cancer of clinical stageⅢ/Ⅳ than those with clinical stageⅠ/Ⅱ(Z=-10.028, P<0.01). The serum levels of IL-10 were significantly higher in patients with cachexia than those without(Z=-10.369, P<0.01). Logistic regression analysis showed that IL-10 was associated with odds ratios of 1.599 (95%CI:1.299-1.870, P<0.01) for cachexia. Conclusion: The serum levels of IL-10 are possibly associated with the occurrence of cachexia from patients with low-third gastric cancer.
