Analysis of metabonomic changes of hepatic vein plasma after oral administration of quercetin in rats
- VernacularTitle:槲皮黄素灌胃后大鼠肝静脉血浆代谢组学的变化及其意义
- Author:
Daizhi AN
;
Qi ZHANG
;
Jingyu WEI
;
Jijun YANG
;
Xianzhong YAN
;
Changjiang GUO
- Publication Type:Journal Article
- Keywords:
Quercetin;
Metabonomics;
Nuclear magnetic resonance
- From:
Parenteral & Enteral Nutrition
2010;17(2):85-88
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the effects of quercetin on hepatic vein metabolic profiles in rats. Methods: Male Wistar rats were administrated orally with 40 mg/kg quercetin. Hepatic vein plasma was collected at 0 h, 0.5 h, 1 h, 2 h and 4 h respectively after administration and analyzed by 1H NMR. Results: The identifiable biochemical effects associated with quercetin dosing included decreased plasma concentration of glucose and increased plasma concentration of succinate,β-hydroxybutyrate and pyruvate. Conclusion: Quercetin changes hepatic metabolism in rats, manifested mainly as increased glucose catabolism and production of ketone bodies.
