Effect of goal of blood glucose control on protein metabolism in the patients with critically cerebral disease
- VernacularTitle:不同血糖控制目标对危重颅脑疾病病人蛋白质代谢的影响
- Author:
Jie ZHAO
;
Jianguo XU
;
Ziqin XU
- Publication Type:Journal Article
- Keywords:
Craniocerebral disease;
Insulin;
Blood glucose;
Protein metabolism
- From:
Parenteral & Enteral Nutrition
2010;17(1):8-10
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the effect of three different goals of blood glucose control by insulin therapy on protein metabolism in the patients with critically cerebral disease.Methods: We performed a prospective,randomized,controlled study.A total of 122 patients with critically cerebral disease were randomly divided into three groups according to the target glucose-control levels:Group A: 4.4-6.1 mmol/L(n=41),Group B: 6.1-8.3 mmol/L(n=42),and Group C: 10-11.1 mmol/L(n=39).The state of protein metabolism and ratio of hypoglycemia of three groups were compared.Results: The indicators of nitrogen balance,prealbumin and transferrin in group A and group B were significantly better than that in group C(P<0.05),but the ratio of hypoglycemia in group A was significantly higher than those in group B and group C(P<0.05).Conclusion: Maintaining the blood glucose level ≤8.3 mmol/L might improve the nutrition status in the patients with critically cerebral disease by decreasing catabolism and promoting synthesis of protein.
