Effect of Omegaven on blood clotting system and inflammatory reaction in ICU patients with parenteral nutrition
- VernacularTitle:ω-3多不饱和脂肪酸对危重症肠外营养病人凝血系统和炎性反应的影响
- Author:
Yanjie ZHANG
;
Zhen YU
;
Jingye PAN
;
Jiangao YAO
;
Xifang LIN
- Publication Type:Journal Article
- Keywords:
Peranteral nutrition;
Coagulapathy;
Inflammation;
Omegaven
- From:Parenteral & Enteral Nutrition
2010;17(1):20-22
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe the changes of blood coagulation factors and inflammatory factors and the regulatin effect of Omegaven.Methods: Thirty ICU patients were randomly allocated into two groups: Omegaven group and control group.Serum concentrations of NF-κB、PGF1α、Eselectin、sICAM-1、TAT、D-dimer、TMD、PF1+2 were measured before and after parenteral nutrition.Results: Patients in control group had significantly higher NF-κB、Eselectin、sICAM-1、TAT、D-dimer、TMD、PF1+2 concentration,lower PGF1α concentration.Patients treated with Omegaven had significantly lower NF-κB、Eselectin、sICAM-1、TAT、D-dimer、TMD、PF1+2 concentration,higher PGF1α concentration.Conclusion: Omegaven can suppress inflammatory reaction and improve coagulopathy.
