Regulation effect of insulin on the hypermetabolism of the skeletal muscles of septic patients through ubiquitin-proteasome pathway
- VernacularTitle:胰岛素通过泛素系统对脓毒症病人骨骼肌代谢的调理作用
- Author:
Qiyi CHEN
;
Wenkui YU
;
Ning LI
- Publication Type:Journal Article
- Keywords:
Insulin;
Ubiquitin-proteasome pathway;
Sepsis;
Hypermetabolism
- From:
Parenteral & Enteral Nutrition
2010;17(1):51-54
- CountryChina
- Language:Chinese
-
Abstract:
Hypermetabolism syndrome,especially in skeletal muscles,is exceedingly common in septic patients.Many studies suggest that the activity of ubiquitin-proteasome pathway is a vital procedure for hypermetabolism of skeletal muscles of septic patients and its activation can be influenced by a variety of factors,such as proinflammatory cytokine and glucocorticoid,etc.Evidences indicate that insulin has played an important role in opsonizing the activation of ubiquitin-proteasome pathway.This paper reviews the regulation effect of insulin to the hypermetabolism of the skeletal muscles of septic patients through ubiquitin-proteasome pathway.
