Long-term influence of splenectomy on immunity in advanced schistosomiasis patients
- VernacularTitle:晚期血吸虫病患者脾切除对免疫功能的远期影响
- Author:
Yiming WU
;
Chenxiao CAI
;
Meiping TU
;
Wenling WU
;
Rengye DING
;
Wenjun ZHU
- Publication Type:Journal Article
- Keywords:
Schistosomiasis;
Splenectomy;
Immunity function
- From:
Chinese Journal of Schistosomiasis Control
2009;21(6):550-552
- CountryChina
- Language:Chinese
-
Abstract:
A total of 55 cases of advanced schistosomiasis patients combined with Ⅲ-grade hepatic fibrosis and ascites were randomized into a splenectomy group and non-splenectomy group. The peripheral vein blood phlebotomized from these patients were detected for leucocytes, hematids, thrombocytes, acidophils, glutamic-pyruvic transaminase,alkaline phosphatase,albumin, total bilirubin,three-type precollagen, fore-type collagen, hyaluronic acid, IgG, IgA, C_3, C_4 and the sub-group of lymphocytes such as CD3、CD4、 CD8 、CD56 + 16. There were no significant difference on hepatic function and the level of hepatic fibrosis between the groups above metioned. It could be found that leucocytes, thrombocytes, IgG, IgA, CD56 + 16 increased while CD3, CD4, and albumin decreased in the splenectomy group. In conclusion, leucocytes and thrombocytes increase after splenectomy, cytoimmunity declines and humoral immunity enhances.
