Morphological changes of enteric deep muscular plexuses interstitial cells of Cajal in rats with multiple organ disfunction syndrome
- VernacularTitle:肠道深部肌间Cajal间质细胞网络在多器官功能障碍综合征时的形态学变化及意义
- Author:
Yi LI
;
Qinghui QI
;
Chao YU
;
Dongliang ZHANG
;
Weiming ZHU
- Publication Type:Journal Article
- Keywords:
Intestitial cells of Cajal;
Gastrointestinal motility;
Intestine;
Multiple organ dysfunction syndrome
- From:Parenteral & Enteral Nutrition
2009;16(6):338-342
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe the morphological changes of enteric deep muscular plexuses interstitial cells of Cajal (ICC-DMP) in rats with multiple organ dysfunction syndrome (MODS). Methods: Forty Wistar rats were randomly divided into control group and MODS model group. The enteric ICC-DMP network was observed using c-kit immunohistochemical staining with whole-mount preparation technique and confocal laser scanning microscopy , and the ultraslructural features of ICC-DMP was evaluated using transmission electron microscope. Results: Compared with those in control group, the distributions and densities of intestine ICC-DMP in MODS group were significantly decreased (P < 0. 05) , the ICC-DMP network was disrupted and the ultrastructural features of ICC-DMP were severely damaged. Conclusion: The ICC-DMP network was severely damaged in rats with MODS, and the mechanism of gastrointestinal dysmotility in MODS may be related to the morphological changes of ICC-DMP.
