The advanced development of Niemann-Pick C1 Like 1
- VernacularTitle:Niemann-Pick C1 Like 1研究新进展
- Author:
Yanfei ZHU
;
Yousheng LI
;
Jieshou LI
- Publication Type:Journal Article
- Keywords:
Niemann-Pick C1 Like 1;
Intestinal cholesterol absorption;
Cholesterol transport
- From:Parenteral & Enteral Nutrition
2009;16(6):373-376
- CountryChina
- Language:Chinese
-
Abstract:
Identification and characterization of Niemann-Pick C1 Like 1 (NPC1L1) has established NPC1L1 as an essential protein in the intestinal cholesterol absorption process,and NPC1L1 is the molecular target of ezetimibe, which is a cholesterol absorption inhibitor. The expression of the gene and protein of NPC1L1 may be regulated by some nuclear receptors. Lack of NPC1L1 auses a nearly complete protection from the development of atherosclerosis in apoE-/- mice c, which provides new target for the treatment for atherosclerosis and cardiovascular disease.
