Influence of ω-3 fatty acids on the therapy of sepsis patients
- VernacularTitle:ω-3脂肪酸对脓毒症病人治疗的影响
- Author:
Yuekun ZOU
;
Yuhong LIU
;
Yan YU
;
Zhicheng ZHANG
- Publication Type:Journal Article
- Keywords:
ω-3 fatty acids;
Fish oil;
Sepsis
- From:
Parenteral & Enteral Nutrition
2009;16(4):222-224
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the immune regulation mechanism and anti-inflammatory effect of ω-3 fatty acids on sepsis patients.Methods: Totle 18 patients were divided into two groups,therapy group and control group. The control group was given routine therapy while the theray group was given routine therapy and fish oil.The expression of HLA-DR on peripheral monocytes was measured by flow cytometry at the beginning and 5 d during therapy, in parallel with serum c-reactive protein(CRP),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),and severity of the disease(APACHE Ⅱ score),serum and oxygenation index(PaO2/FiO2)Results: Compared with conventional group,serum concentration of CRP, IL-6 and TNF-α in patients of therapy group were significantly reduced,and oxygenation index improved. There was no difference in the expression of HLA-DR and APACHE Ⅱscore between two groups.Conclusion:Fish oil can decrease the elevated mediators of inflammation on sepsis patients,and can't regulation the expression of HLA-DR on peripheral monocytes.
