Post -hemodialytic urea rebound and its impact factors in maintenance hemodialysis patients

VernacularTitle:维持性血液透析后血清尿素反弹及其影响因素
Author: Jia LU ; Shaowei XU ; Xiaoqiang DING ; Jianzhou ZOU ; Zhonghua LIU ; Bo SHEN ; Jie TENG
Publication Type:Journal Article
Keywords: Hemodialysis; Urea; Urea rebound; Hemodialysis adequacy
From: Chinese Journal of Nephrology 2011;27(7):495-498
CountryChina
Language:Chinese
Abstract: Objective To study the urea rebound after hemodialysis in maintenance hemodialysis (MHD) patients and its impact factors. Methods From 124 stable MHD patients, blood samples were collected at the beginning, immediate post-hemodialysis, 15 minutes and 30 minutes after hemodialysis. The urea rebound was quantified, and its effect on URR and spKt/V was investigated. The impact factors on urea rebound were analyzed. Results In this group of patients, average post-hemodialytic urea rebound was 13.6%, leading to over-estimation of URR and spKt/V of 0.04 and 0.14, respectively. Hemodialysis efficiency expressed as K/V determined urea rebound most significantly. Other impact factors included higher hemoglobin, higher relative ultrafiltration, arteriovenous access, and male patients. Conclusions Urea rebound is common after the hemodialysis. For specific patients and hemodialysis sessions, ignoring it would result in significant over-estimation of delivered hemodialysis dose.