The analysis of progression of ischemic leukoaraiosis and the risk factors in elderly patients

VernacularTitle:高龄患者缺血性脑白质疏松进展的相关危险因素分析
Author: Xinguo HU ; Na LI ; Ling CHENG ; Weiping WU ; Weiping GUAN
Publication Type:Journal Article
Keywords: Leukoaraiosis; Cysteine; Bronchitis,chronic
From: Chinese Journal of Geriatrics 2011;30(7):537-539
CountryChina
Language:Chinese
Abstract: Objective To study the features and risk factors of ischemic leukoaraiosis (LA) progression in elderly patients aged 80 years and over. Methods The 56 elderly patients with ischemic LA confirmed by MRI were enrolled in this study. The characteristics and risk factors of ischemic LA were comparatively analyzed between baseline and 3 years later by single and multi-variable logistic regression analysis. Results Ischemic LA progressed mostly in the subcortical white matter in elderly patients, especially the frontal lobes (progression of white matter lesion was present in 40% in the frontal lobes at baseline and 52% after 3 years), followed by the parietal lobes (35% at baseline and 36% after 3 years); Furthermore, previous high homocysteine (Hcy) and chronic bronchitis were risk factors of ischemic LA progression. Conclusions Ischemic LA progresses mostly in the subcortical white matter in the elderly, especially the frontal lobes; High Hcy and chronic bronchitis are risk factors of ischemic LA progression in elderly patients.