Clinical analysis of 48 cases with atypical endometrial hyperplasia

VernacularTitle:子宫内膜非典型增生48例临床分析
Author: Anxia WAN ; Ping JIANG
Publication Type:Journal Article
Keywords: Endometrial hyperplasia; Endometrial neoplasms; Dilatation and curettage
From: Chinese Journal of Geriatrics 2011;30(6):495-497
CountryChina
Language:Chinese
Abstract: Objective To evaluate the role of the fractional dilatation and curettage (D&C) in the diagnosis of atypical hyperplasia of endometrium. Methods The retrospective analysis was performed in 48 patients diagnosed as atypical hyperplasia of endometrium and treated in our hospital from Aug.2009 to Dec.2010. We compared the pathology results of D&C with hysterectomy specimens, and investigated the reasons for the difference. Results The six patients (12.5%) with mild atypical hyperplasia of endometrium still presented with significant pathological changes after D&C (χ2 = 5.90, P＜0.05), 11 cases (22.9%) in 14 patients(29.2%) with moderate atypical hyperplasia (χ2=0.49, P＞0.01), 18 cases (100%) in patents with serious atypical hyperplasia, among which even 8 patients (44.4%) were verified as endometrial cancer. Conclusions There exists pathological discrepancy between the fractional D&C and hysterectomy specimens. Patients with severer atypical hyperplasia may have a higher risk of developing endometrial cancer.